Tesofensine (500mcg Capsules) x 30

Tesofensine (500mcg Capsules) – Overview

What is Tesofensine?

Tesofensine is a centrally acting appetite suppressant originally developed for neurodegenerative conditions but found to be highly effective in promoting weight loss. It works by inhibiting the reuptake of dopamine, serotonin, and norepinephrine, resulting in reduced appetite, enhanced satiety, and increased metabolic activity. Tesofensine is taken orally and is often included in weight management protocols.

For Practitioners: Clinical Guidance

Mechanism of Action

Tesofensine is a triple monoamine reuptake inhibitor that elevates levels of dopamine, serotonin, and norepinephrine in the brain. This combination not only suppresses appetite but also increases motivation and energy expenditure. Unlike stimulant-based weight loss agents, Tesofensine acts primarily via the hypothalamus, making it effective without high cardiovascular stimulation.

Benefits

• Potent appetite suppressant and satiety enhancer
• Promotes consistent, sustainable fat loss
• Increases resting energy expenditure and metabolic rate
• May improve mood, focus, and motivation
• Low risk of addiction or stimulant-like crash

Dosing Protocol

• Typical Dose: 500 mcg (0.5 mg) capsule once daily
• Timing: Morning, with or without food
• Cycle Duration: 8–12 weeks; can be extended depending on response and tolerance
• Titration: Begin with lower dose (250 mcg) if sensitivity is suspected

Monitoring

• Monitor weight, appetite, and dietary habits
• Track blood pressure and heart rate regularly
• Assess mood, energy, and sleep quality
• Optional labs: fasting glucose, lipids, thyroid function if used long-term

For Patients: What You Should Know

What It Does

Tesofensine helps reduce appetite and cravings while boosting your metabolism. It makes you feel full faster, eat less, and burn more calories—helping with long-term fat loss goals.

Why You Might Use It

• Struggling with portion control or constant hunger
• Looking to jumpstart weight loss or break through a plateau
• Wanting more energy and focus while dieting
• Interested in a non-stimulant, prescription-grade fat loss option

How to Take It

• Take one 500 mcg capsule in the morning
• Can be taken with or without food
• Avoid taking late in the day to prevent sleep disturbances
• Follow your practitioner’s instructions carefully

What to Expect

• Decreased hunger and fewer food cravings within days
• Steady fat loss when combined with a healthy diet and exercise
• Improved energy, mood, and focus throughout the day

Possible Side Effects

• Dry mouth, insomnia, or mild anxiety (especially early on)
• Headache, nausea, or increased heart rate (less common)
• Rare: blood pressure elevation—report any concerns to your provider

Tesofensine is a powerful and effective tool for weight loss and appetite control—speak with your practitioner to see how it fits into your personalized weight management plan.