PT-141 (10mg)

PT-141 – Overview

What is PT-141?

PT-141 (Bremelanotide) is a synthetic peptide originally developed from Melanotan II. It is FDA-approved for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women and is used off-label to enhance libido in both men and women. Unlike other treatments that work hormonally or through blood flow, PT-141 acts on the central nervous system to directly influence sexual desire and arousal.

For Practitioners: Clinical Guidance

Mechanism of Action

PT-141 binds to melanocortin receptors in the brain, particularly MC3R and MC4R, which are associated with sexual arousal pathways. It stimulates the hypothalamus to promote sexual desire independently of hormonal pathways or vasodilation, making it effective even in cases where PDE5 inhibitors (e.g., Viagra) are not.

Benefits

• Enhances libido in both men and women
• Increases sexual arousal and satisfaction
• Effective even in cases of low hormone levels or psychological inhibition
• Non-hormonal and not dependent on blood flow
• May support mood and energy levels due to central nervous system activation

Dosing Protocol

• Typical Dose: 1.25–2 mg per dose
• Frequency: As needed, typically 30–60 minutes before sexual activity
• Route: Subcutaneous injection (also available as nasal spray in FDA-approved formulation)
• Cycle Duration: Can be used intermittently or regularly depending on patient goals

Monitoring

• Monitor response in terms of arousal, desire, and satisfaction
• Assess for potential side effects like flushing or nausea
• Discuss expectations and psychological factors influencing sexual function

For Patients: What You Should Know

What It Does

PT-141 helps increase sexual desire by working directly in your brain’s arousal centers. It can improve your interest in intimacy and enhance physical responses, regardless of hormonal levels or blood flow.

Why You Might Use It

• Experiencing low sex drive or lack of arousal
• Wanting to enhance intimacy and sexual satisfaction
• Looking for a non-hormonal alternative to traditional treatments
• Struggling with desire despite healthy relationships and hormone levels

How to Take It

• Inject under the skin (often in the abdomen) 30–60 minutes before desired effect
• Use only as needed—not a daily medication unless advised otherwise
• Always follow your practitioner’s prescribed dose and timing

What to Expect

• Increased desire and mental readiness for intimacy
• Enhanced arousal and overall sexual experience
• Effects can last 6–12 hours after dosing

Possible Side Effects

• Flushing, facial warmth, or increased skin sensitivity
• Nausea (dose-dependent), headache, or temporary blood pressure changes
• Rare: injection site irritation or mild dizziness

PT-141 is a safe, centrally acting option to enhance sexual wellness—speak with your practitioner about how it fits into your health and relationship goals.